Saints will welcome back Artur Boruc as they face Aston Villa.
The Saints manager is hoping to see his side bounce back to winning ways after the disappointing home defeat to Cardiff.
“It is very different teams and it will be a different game,” said Pochettino.
“We were quite unlucky against Cardiff because we deserved more from that game, we did everything to win that game but it wasn’t to be for us that day.
“I think it was one of the easiest games we could have won but it didn’t happen in the end.
“Now against Aston Villa we know we are going to be facing a very tough team, a very physical side and a very difficult ground but our focus is always to win.”