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World Cup hopes on the line for Saints trio
While Lambert and Saints keeper Artur Boruc will go head-to-head at Wembley as England try to secure first place in Group H and a spot in Brazil next year, there are still other matters to be decided in what is a crucial last round of fixtures for a number of nations.
Lovren will be desperately hoping that Croatia can get a result in Scotland.
Though their chances of qualifying automatically for the World Cup have gone, they should bag a play-off place in Group A.
However, to be totally sure they have a good enough record they need a result in Scotland.
Also living life on the edge is Ramirez and Uruguay.
Their chances of bagging an automatic qualifying place from the South American group are slim, but not entirely impossible.
They do have the task of beating Argentina at home to make it a possibility, and will rely on a clear winner in the game between Chile and Ecuador.
Then it will come down to the maths with the margins of victory needing to be wide enough.
If those two results happened then Uruguay would finish level on points with the losers of the Chile and Ecuador game and would need to overturn a six-goal deficit to finish above Ecuador and a four-goal deficit to get above Chile.
If they fail to do that then they will almost inevitably have to settle for a two-legged play-off against Jordan to try and book their place.
There is less riding on the results for a few other Saints stars.
Dani Osvaldo scored for Italy at the weekend and is hoping to follow that up as his country host Armenia, having already sealed first place in Group B.
Steven Davis is set to captain Northern Ireland in Israel in Group F, however there is no chance they can qualify.
The same applies to Wales who travel to Belgium in Group F, but that won’t stop Lloyd Isgrove from hoping to win his first full cap.
The other Saint in action at senior level is Maya Yoshida who plays in a friendly against Belarus.
James Ward-Prowse is hoping for another appearance for the England under-21s as they continue their European Championship qualifying campaign against Lithuania.
Calum Chambers can help book the England under-19s a place in the European Championships Elite round next year if they can avoid defeat against Switzerland.
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